Exchange 2016 receiving error message:

"Message or connection acked with status Retry and response 441 4.4.1 Error encountered while communicating with primary target IP address: ""Failed to connect. Winsock error code: 10061, Win32 error code: 10061."" Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts. The last endpoint attempted was"

451 4.7.0 Temporary server error. Please try again later. PRX5 ,Duration(ms):1665

451 4.7.0 Timeout waiting for client input,


Cisco ASA ESMTP inspection is set to default inspection map. Make sure it’s turned off. Chances are the sender’s address length is greater than 320 or the body line length is greater than 998.